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KMID : 0370220160600030141
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Yakhak Hoeji
2016 Volume.60 No. 3 p.141 ~ p.145
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Study on Lifespan Extension Effect of Leonurine and its Synthetic Fragmental Analogs on Caenorhabditis elegans
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Cha Dong-Seok
Han Young-Taek
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Abstract
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The current study was conducted to evaluate the lifespan extension effects of leonurine and its synthetic fragmental analogs using Caenohabditis elegans model system. Leonurine significantly prolonged the lifespan of C. elegans in a dose-dependent manner. To dissect the structure-activity relationship between leonurine and lifespan extension activity, seven novel fragmental analogs were synthesized and evaluated. Our study revealed that benzoate part of leonurine is responsible for its lifespan extension property rather than quanidine moiety.
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KEYWORD
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leonurine, lifespan extension, synthesis, fragmental analog, Caenorhabditis elegans, structure-activity relationship
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FullTexts / Linksout information
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Listed journal information
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